Signal Transduction Antibodies 1
Anti-ABCB10 Antibody (CAB13787)
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- SKU:
- CAB13787
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ABCB10 Antibody |
| Antibody SKU: | CAB13787 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-300 of human ABCB10 (NP_036221.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, Raji, Mouse brain, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-300 of human ABCB10 (NP_036221.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AIRV YLMQ TSGQ RIVN RLRT SLFS SILR QEVA FFDK TRTG ELIN RLSS DTAL LGRS VTEN LSDG LRAG AQA |
| Gene ID: | 23456 |
| Uniprot: | Q9NRK6 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 79kDa |
| Observed MW: | 80kDa |
| Synonyms: | ABCB10, EST20237, M-ABC2, MTABC2 |
| Background: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. |
| UniProt Protein Function: | ABCB10: May mediate critical mitochondrial transport functions related to heme biosynthesis. Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral; Hydrolase; Transporter, ABC family Chromosomal Location of Human Ortholog: 1q42.13 Molecular Function:ATPase activity, coupled to transmembrane movement of substances Biological Process: transmembrane transport |
| NCBI Summary: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRK6 |
| NCBI GenInfo Identifier: | 171184400 |
| NCBI Gene ID: | 23456 |
| NCBI Accession: | NP_036221.2 |
| UniProt Secondary Accession: | Q9NRK6,Q13040, Q6P1Q8, Q9H3V0, |
| UniProt Related Accession: | Q9NRK6 |
| Molecular Weight: | 79,148 Da |
| NCBI Full Name: | ATP-binding cassette sub-family B member 10, mitochondrial |
| NCBI Synonym Full Names: | ATP binding cassette subfamily B member 10 |
| NCBI Official Symbol: | ABCB10 |
| NCBI Official Synonym Symbols: | M-ABC2; MTABC2; EST20237 |
| NCBI Protein Information: | ATP-binding cassette sub-family B member 10, mitochondrial |
| UniProt Protein Name: | ATP-binding cassette sub-family B member 10, mitochondrial |
| UniProt Synonym Protein Names: | ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 |
| Protein Family: | ABC transporter B family |
| UniProt Gene Name: | ABCB10 |
| UniProt Entry Name: | ABCBA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ABCB10 antibody (CAB13787) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of C6 cells using ABCB10 antibody (CAB13787) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using ABCB10 antibody (CAB13787) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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