Cell Biology Antibodies 18
Anti-ABCA7 Antibody (CAB18280)
- SKU:
- CAB18280
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-ABCA7 Antibody |
Antibody SKU: | CAB18280 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human ABCA7. |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | Rat brain |
Immunogen: | Recombinant protein of human ABCA7. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 10347 |
Uniprot: | Q8IZY2 |
Cellular Location: | |
Calculated MW: | 234kDa |
Observed MW: | 260KDa |
Synonyms: | ABCA7, ABCA-SSN, ABCX, AD9 |
Background: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. |
UniProt Protein Function: | Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. Plays a role in phagocytosis of apoptotic cells by macrophages. Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7. Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages. Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). |
NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8IZY2 |
NCBI GenInfo Identifier: | 161784300 |
NCBI Gene ID: | 10347 |
NCBI Accession: | Q8IZY2.3 |
UniProt Secondary Accession: | Q8IZY2,Q96S58, Q9BZC4, Q9NR73, Q9UKP8, |
UniProt Related Accession: | Q8IZY2 |
Molecular Weight: | 218,497 Da |
NCBI Full Name: | ATP-binding cassette sub-family A member 7 |
NCBI Synonym Full Names: | ATP binding cassette subfamily A member 7 |
NCBI Official Symbol: | ABCA7 |
NCBI Official Synonym Symbols: | AD9; ABCX; ABCA-SSN |
NCBI Protein Information: | ATP-binding cassette sub-family A member 7 |
UniProt Protein Name: | ATP-binding cassette sub-family A member 7 |
UniProt Synonym Protein Names: | ABCA-SSN; Autoantigen SS-N; Macrophage ABC transporter |
Protein Family: | ABC transporter A family |
UniProt Gene Name: | ABCA7 |