| Synonyms: | ABCA7, ABCA-SSN, ABCX, AD9 |
| Background: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. |
| UniProt Protein Function: | Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. Plays a role in phagocytosis of apoptotic cells by macrophages. Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7. Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages. Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). |
| NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IZY2 |
| NCBI GenInfo Identifier: | 161784300 |
| NCBI Gene ID: | 10347 |
| NCBI Accession: | Q8IZY2.3 |
| UniProt Secondary Accession: | Q8IZY2,Q96S58, Q9BZC4, Q9NR73, Q9UKP8, |
| UniProt Related Accession: | Q8IZY2 |
| Molecular Weight: | 218,497 Da |
| NCBI Full Name: | ATP-binding cassette sub-family A member 7 |
| NCBI Synonym Full Names: | ATP binding cassette subfamily A member 7 |
| NCBI Official Symbol: | ABCA7 |
| NCBI Official Synonym Symbols: | AD9; ABCX; ABCA-SSN |
| NCBI Protein Information: | ATP-binding cassette sub-family A member 7 |
| UniProt Protein Name: | ATP-binding cassette sub-family A member 7 |
| UniProt Synonym Protein Names: | ABCA-SSN; Autoantigen SS-N; Macrophage ABC transporter |
| Protein Family: | ABC transporter A family |
| UniProt Gene Name: | ABCA7 |
