Anti-AANAT Antibody (CAB7863)
- SKU:
- CAB7863
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AANAT
- Synonyms:
- DSPS
- Synonyms:
- SNAT
- Research Area:
- Cell Biology
Description
| Product Name: | AANAT Rabbit pAb |
| Product Code: | CAB7863 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AANAT, DSPS, SNAT |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human AANAT (NP_001079.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human AANAT (NP_001079.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSTQ STHP LKPE APRL PPGI PESP SCQR RHTL PASE FRCL TPED AVSA FEIE REAF ISVL GVCP LYLD EIRH FLTL CPEL SLGW FEEG CLVA FIIG SLWD KERL MQES LTLH RSGG HIAH LHVL AVHR AFRQ QGRG PILL WRYL HHLG SQPA VRRA ALMC EDAL VPFY ERFS FHAV GPCA ITVG SLTF MELH CSLR GHPF LRRN SGC |
| Gene ID: | 15 |
| Uniprot: | Q16613 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 23kDa/28kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | AA-NAT var1: Catalyzes the N-acetylation of serotonin into N- acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines. Belongs to the acetyltransferase family. AANAT subfamily. Monomer. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect. |
| UniProt Protein Details: | Protein type:Acetyltransferase; EC 2.3.1.87; Amino Acid Metabolism - tryptophan Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: perinuclear region of cytoplasm; cytosol Molecular Function:arylamine N-acetyltransferase activity; aralkylamine N-acetyltransferase activity Biological Process: circadian rhythm; N-terminal protein amino acid acetylation; response to light stimulus; melatonin biosynthetic process; response to copper ion; response to zinc ion; indolalkylamine biosynthetic process; response to cytokine stimulus; response to calcium ion; response to corticosterone stimulus; response to insulin stimulus Disease: Delayed Sleep Phase Syndrome, Susceptibility To |
| NCBI Summary: | The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q16613 |
| NCBI GenInfo Identifier: | 11387096 |
| NCBI Gene ID: | 15 |
| NCBI Accession: | Q16613.1 |
| UniProt Secondary Accession: | Q16613,Q562F4, A0AVF2, J3KMZ5, |
| UniProt Related Accession: | Q16613 |
| Molecular Weight: | 28,432 Da |
| NCBI Full Name: | Serotonin N-acetyltransferase |
| NCBI Synonym Full Names: | aralkylamine N-acetyltransferase |
| NCBI Official Symbol: | AANAT |
| NCBI Official Synonym Symbols: | DSPS; SNAT |
| NCBI Protein Information: | serotonin N-acetyltransferase; serotonin acetylase; arylalkylamine N-acetyltransferase |
| UniProt Protein Name: | Serotonin N-acetyltransferase |
| UniProt Synonym Protein Names: | Aralkylamine N-acetyltransferase; AA-NAT |
| Protein Family: | Serotonin N-acetyltransferase |
| UniProt Gene Name: | AANAT |
| UniProt Entry Name: | SNAT_HUMAN |
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