Metabolism Antibodies 3

Anti-A4GALT Antibody (CAB8817)

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SKU:
CAB8817
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-A4GALT Antibody
Antibody SKU:CAB8817
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 244-353 of human A4GALT (NP_059132.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, LO2, A375, HeLa, Mouse kidney, Mouse brain, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 244-353 of human A4GALT (NP_059132.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WIWG HQGP QLLT RVFK KWCS IRSL AESR ACRG VTTL PPEA FYPI PWQD WKKY FEDI NPEE LPRL LSAT YAVH VWNK KSQG TRFE ATSR ALLA QLHA RYCP TTHE AMKM YL
Gene ID:53947
Uniprot:Q9NPC4
Cellular Location:Golgi apparatus membrane, Single-pass type II membrane protein
Calculated MW:40kDa
Observed MW:45kDa
Synonyms:A4GALT, A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK, PK
Background:The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.
UniProt Protein Details:

Protein type:Contractile; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function:protein kinase binding; ATP binding

Biological Process: muscle contraction; regulation of blood pressure; response to virus; vascular smooth muscle contraction

Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6

NCBI Summary:The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
UniProt Code:Q9NPC4
NCBI GenInfo Identifier:8392830
NCBI Gene ID:53947
NCBI Accession:NP_059132
UniProt Related Accession:Q9NPC4
Molecular Weight:40kDa
NCBI Full Name:lactosylceramide 4-alpha-galactosyltransferase
NCBI Synonym Full Names:alpha 1,4-galactosyltransferase (P blood group)
NCBI Official Symbol:A4GALT  
NCBI Official Synonym Symbols:P1; PK; Gb3S; P(k); P1PK; A14GALT; A4GALT1  
NCBI Protein Information:lactosylceramide 4-alpha-galactosyltransferase
UniProt Protein Name:Actin, aortic smooth muscle
UniProt Synonym Protein Names:Alpha-actin-2; Cell growth-inhibiting gene 46 protein
Protein Family:Actin
UniProt Gene Name:ACTA2  
UniProt Entry Name:ACTA_HUMAN
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