Cell Biology Antibodies 7
Anti-A2M Antibody (CAB16336)
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- SKU:
- CAB16336
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-A2M Antibody |
| Antibody SKU: | CAB16336 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human A2M (NP_000005.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human A2M (NP_000005.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALAG NQDK RKEV LKSL NEEA VKKD NSVH WERP QKPK APVG HFYE PQAP SAEV EMTS YVLL AYLT AQPA PTSE DLTS ATNI VKWI TKQQ NAQG GFSS TQDT VVAL HALS KYGA ATFT RTGK AAQV TIQS SGTF SSKF QVDN NNRL LLQQ VSLP ELPG EYSM KVTG EGCV YLQT SLKY NILP EKEE FPFA LGVQ TLPQ TCDE PKAH TSFQ ISLS VSYT GSRS ASNM AIVD VKMV SGFI PLKP TVKM LERS NHVS RTEV SSNH VLIY LDKV SNQT LSLF FTVL QDVP VRDL KPAI VKVY DYYE TDEF AIAE YNAP CSKD LGNA |
| Gene ID: | 2 |
| Uniprot: | P01023 |
| Cellular Location: | Secreted |
| Calculated MW: | 163kDa |
| Observed MW: | Refer to figures |
| Synonyms: | A2M, A2MD, CPAMD5, FWP007, S863-7 |
| Background: | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. |
| UniProt Protein Function: | Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| UniProt Protein Details: | Subunit structure: Homotetramer; disulfide-linked. Ref.8 Ref.10 Subcellular location: Secreted Ref.8. Tissue specificity: Secreted in plasma. Ref.8 Developmental stage: Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation. Sequence similarities: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification] Sequence caution: The sequence AAT02228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAD92851.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. |
| NCBI Summary: | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq] |
| UniProt Code: | P01023 |
| NCBI GenInfo Identifier: | 112911 |
| NCBI Gene ID: | 2 |
| NCBI Accession: | P01023.1 |
| UniProt Secondary Accession: | P01023,Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97 |
| UniProt Related Accession: | P01023,Q9BQ22 |
| Molecular Weight: | 163,291 Da |
| NCBI Full Name: | Alpha-2-macroglobulin |
| NCBI Synonym Full Names: | alpha-2-macroglobulin |
| NCBI Official Symbol: | A2M |
| NCBI Official Synonym Symbols: | A2MD; CPAMD5; FWP007; S863-7; DKFZp779B086 |
| NCBI Protein Information: | alpha-2-macroglobulin; alpha-2-M; OTTHUMP00000196829; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 |
| UniProt Protein Name: | Alpha-2-macroglobulin |
| UniProt Synonym Protein Names: | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 |
| Protein Family: | Alpha-2-macroglobulin |
| UniProt Gene Name: | A2M |
| UniProt Entry Name: | A2MG_HUMAN |
 | Immunohistochemistry of paraffin-embedded human placenta using A2M antibody (CAB16336) at dilution of 1:100 (40x lens). |
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