Cell Biology Antibodies 1

Anti-4-1BBL/CD137L Antibody (CAB10202)

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SKU:
CAB10202
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-4-1BBL/CD137L Antibody
Antibody SKU:CAB10202
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 55-254 of human 4-1BBL/CD137L (NP_003802.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HT-1080, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 55-254 of human 4-1BBL/CD137L (NP_003802.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VSGA RASP GSAA SPRL REGP ELSP DDPA GLLD LRQG MFAQ LVAQ NVLL IDGP LSWY SDPG LAGV SLTG GLSY KEDT KELV VAKA GVYY VFFQ LELR RVVA GEGS GSVS LALH LQPL RSAA GAAA LALT VDLP PASS EARN SAFG FQGR LLHL SAGQ RLGV HLHT EARA RHAW QLTQ GATV LGLF RVTP EIPA GLPS PRSE
Gene ID:8744
Uniprot:P41273
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:26kDa
Observed MW:26kDa
Synonyms:TNFSF9, 4-1BB-L, CD137L, TNLG5A
Background:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
UniProt Protein Function:TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family.
UniProt Protein Details:

Protein type:Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: plasma membrane

Molecular Function:receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: apoptosis; cell proliferation; cell-cell signaling; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; signal transduction; tumor necrosis factor-mediated signaling pathway

NCBI Summary:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
UniProt Code:P41273
NCBI GenInfo Identifier:728739
NCBI Gene ID:8744
NCBI Accession:P41273.1
UniProt Secondary Accession:P41273,Q2M3S2,
UniProt Related Accession:P41273
Molecular Weight:27kDa
NCBI Full Name:Tumor necrosis factor ligand superfamily member 9
NCBI Synonym Full Names:TNF superfamily member 9
NCBI Official Symbol:TNFSF9  
NCBI Official Synonym Symbols:CD137L; TNLG5A; 4-1BB-L  
NCBI Protein Information:tumor necrosis factor ligand superfamily member 9
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 9
UniProt Synonym Protein Names:4-1BB ligand; 4-1BBL
Protein Family:Tumor necrosis factor ligand superfamily
UniProt Gene Name:TNFSF9  
Anti-4-1BBL/CD137L Antibody (CAB10202)Western blot analysis of extracts of various cell lines, using 4-1BBL/CD137L antibody (CAB10202) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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