Immunology Antibodies 2

Anti-4-1BB/CD137 Antibody (CAB2025)

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SKU:
CAB2025
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-4-1BB/CD137 Antibody
Antibody SKU:CAB2025
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human 4-1BB/CD137 (NP_001552.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse spleen, Rat spleen
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human 4-1BB/CD137 (NP_001552.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GTKE RDVV CGPS PADL SPGA SSVT PPAP AREP GHSP QIIS FFLA LTST ALLF LLFF LTLR FSVV KRGR KKLL YIFK QPFM RPVQ TTQE EDGC SCRF PEEE E
Gene ID:3604
Uniprot:Q07011
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:27kDa
Observed MW:27kDa
Synonyms:TNFRSF9, 4-1BB, CD137, CDw137, ILA
Background:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
UniProt Protein Function:TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function:cytokine binding; receptor activity

Biological Process: negative regulation of cell proliferation; apoptosis

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Code:Q07011
NCBI GenInfo Identifier:728738
NCBI Gene ID:3604
NCBI Accession:Q07011.1
UniProt Related Accession:Q07011,AAB34924
Molecular Weight:27,899 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 9
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 9
NCBI Official Symbol:TNFRSF9  
NCBI Official Synonym Symbols:ILA; 4-1BB; CD137; CDw137  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 9
UniProt Synonym Protein Names:4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137
UniProt Gene Name:TNFRSF9  
UniProt Entry Name:TNR9_HUMAN
Anti-4-1BB/CD137 Antibody (CAB2025)Western blot analysis of extracts of various cell lines, using 4-1BB/CD137 antibody (CAB2025) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-4-1BB/CD137 Antibody (CAB2025)Immunohistochemistry of paraffin-embedded Mouse spleen using 4-1BB/CD137 Rabbit pAb (CAB2025) at dilution of 1:100 (40x lens).
Anti-4-1BB/CD137 Antibody (CAB2025)Immunohistochemistry of paraffin-embedded Rat spleen using 4-1BB/CD137 Rabbit pAb (CAB2025) at dilution of 1:100 (40x lens).
Anti-4-1BB/CD137 Antibody (CAB2025)Immunohistochemistry of paraffin-embedded Human spleen using 4-1BB/CD137 Rabbit pAb (CAB2025) at dilution of 1:100 (40x lens).
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