ANKRD11 Antibody (PACO49218)
- SKU:
- PACO49218
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ANKRD11 Antibody (PACO49218) |
| Antibody SKU: | PACO49218 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Ankyrin repeat domain-containing protein 11 protein (1002-1276AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis (By similarity). |
| Synonyms: | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1), ANKRD11, ANCO1 |
| UniProt Protein Function: | ANKRD11: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Defects in ANKRD11 are the cause of KBG syndrome (KBGS). A syndrome characterized by macrodontia of the upper central incisors, distinctive craniofacial findings, short stature, skeletal anomalies, and neurologic involvement that includes global developmental delay, seizures, and intellectual disability.Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 16q24.3Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleusBiological Process: in utero embryonic development; skeletal morphogenesis; multicellular organism growth; tissue homeostasis; odontogenesis of dentine-containing teethDisease: Kbg Syndrome |
| UniProt Protein Details: | |
| NCBI Summary: | This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q6UB99 |
| NCBI GenInfo Identifier: | 371874367 |
| NCBI Gene ID: | 29123 |
| NCBI Accession: | NP_001243112.1 |
| UniProt Secondary Accession: | Q6UB99,Q6NTG1, Q6QMF8 |
| UniProt Related Accession: | Q6UB99 |
| Molecular Weight: | 297,913 Da |
| NCBI Full Name: | ankyrin repeat domain-containing protein 11 |
| NCBI Synonym Full Names: | ankyrin repeat domain 11 |
| NCBI Official Symbol: | ANKRD11 |
| NCBI Official Synonym Symbols: | T13; LZ16; ANCO1; ANCO-1 |
| NCBI Protein Information: | ankyrin repeat domain-containing protein 11; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein |
| UniProt Protein Name: | Ankyrin repeat domain-containing protein 11 |
| UniProt Synonym Protein Names: | Ankyrin repeat-containing cofactor 1 |
| Protein Family: | Ankyrin repeat domain-containing protein |
| UniProt Gene Name: | ANKRD11 |
| UniProt Entry Name: | ANR11_HUMAN |
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