ANG1 Antibody (PACO33500)

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SKU:
PACO33500
Product Type:
Antibody
Reactivity:
Bovine
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

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Antibody Name:ANG1 Antibody (PACO33500)
Antibody SKU:PACO33500
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Bovine
Immunogen:Recombinant Bovine Angiogenin-1 protein (24-148AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.
Synonyms:Angiogenin-1 (EC 3.1.27.-), ANG1, ANG
UniProt Protein Function:Function: Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) By similarity. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.Subunit structure: Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur By similarity.Subcellular location: Secreted › extracellular space › extracellular matrix › basement membrane. Nucleus › nucleolus By similarity. Note: Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA By similarity.Tissue specificity: Serum and milk.Sequence similarities: Belongs to the pancreatic ribonuclease family.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P10152
NCBI GenInfo Identifier:20455472
NCBI Gene ID:
NCBI Accession:P10152.4
UniProt Secondary Accession:P10152,Q9GKP9
UniProt Related Accession:P10152
Molecular Weight:15.8kDa
NCBI Full Name:Angiogenin-1
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Angiogenin-1
UniProt Synonym Protein Names:
Protein Family:Angiogenin
UniProt Gene Name:ANG1  
UniProt Entry Name:ANG1_BOVIN
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