ANAPC4 Antibody (PACO18571)
- SKU:
- PACO18571
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ANAPC4 Antibody (PACO18571) |
| Antibody SKU: | PACO18571 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human ANAPC4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18571(ANAPC4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18571(ANAPC4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | anaphase promoting complex subunit 4 |
| UniProt Protein Function: | APC4: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC4 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 4p15.2 Cellular Component: nucleoplasm; anaphase-promoting complex; nucleus; cytosol Molecular Function:protein binding; ubiquitin-protein ligase activity; protein phosphatase binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
| NCBI Summary: | A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
| UniProt Code: | Q9UJX5 |
| NCBI GenInfo Identifier: | 205371737 |
| NCBI Gene ID: | 29945 |
| NCBI Accession: | Q9UJX5.2 |
| UniProt Related Accession: | Q9UJX5 |
| Molecular Weight: | |
| NCBI Full Name: | Anaphase-promoting complex subunit 4 |
| NCBI Synonym Full Names: | anaphase promoting complex subunit 4 |
| NCBI Official Symbol: | ANAPC4 |
| NCBI Official Synonym Symbols: | APC4 |
| NCBI Protein Information: | anaphase-promoting complex subunit 4 |
| UniProt Protein Name: | Anaphase-promoting complex subunit 4 |
| UniProt Synonym Protein Names: | Cyclosome subunit 4 |
| Protein Family: | Acetophenone carboxylase |
| UniProt Gene Name: | ANAPC4 |
| UniProt Entry Name: | APC4_HUMAN |
| Antibodies |
| ANAPC4 Antibody (PACO07728) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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