AMZ1 Antibody (PACO19144)
- SKU:
- PACO19144
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | AMZ1 Antibody (PACO19144) |
| Antibody SKU: | PACO19144 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human AMZ1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, Human liver tissue, Primary antibody: PACO19144(AMZ1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19144(AMZ1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | AMZ1 shares sequence similarity with archaeal metalloproteases called archaemetzincins, but it appears to act predominantly as a basic aminopeptidase. Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively. |
| Synonyms: | archaelysin family metallopeptidase 1 |
| UniProt Protein Function: | AMZ1: Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family.Protein type: Protease; EC 3.-.-.-Chromosomal Location of Human Ortholog: 7p22.3 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q400G9 |
| NCBI GenInfo Identifier: | 85540611 |
| NCBI Gene ID: | 155185 |
| NCBI Accession: | Q400G9.1 |
| UniProt Secondary Accession: | Q400G9,Q8TF51, B3KRS0 |
| UniProt Related Accession: | Q400G9 |
| Molecular Weight: | 31,860 Da |
| NCBI Full Name: | Archaemetzincin-1 |
| NCBI Synonym Full Names: | archaelysin family metallopeptidase 1 |
| NCBI Official Symbol: | AMZ1 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | archaemetzincin-1 |
| UniProt Protein Name: | Archaemetzincin-1 |
| UniProt Synonym Protein Names: | Archeobacterial metalloproteinase-like protein 1 |
| Protein Family: | Archaemetzincin |
| UniProt Gene Name: | AMZ1 |
| UniProt Entry Name: | AMZ1_HUMAN |
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