β-Amyloid(1-40) Monoclonal Antibody
- SKU:
- CAB24949
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | β-Amyloid(1-40) Monoclonal Antibody |
| Product Code: | CAB24949 |
| Reactivity: | Mouse |
| Applications: | Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC65337 |
| Reactivity: | Mouse |
| Tested Applications: | IHC-P, IF/ICC, ELISA |
| Key Applications: | Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Membrane, Single-pass type I membrane protein, clathrin-coated pit |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 671-770 of human β-Amyloid(1-40)(NP_000475.1). |
| Sequence: | MDAEF RHDSG YEVHH QKLVF FAEDV GSNKG AIIGL MVGGV VIATV IVITL VMLKK KQYTS IHHGV VEVDA AVTPE ERHLS KMQQN GYENP TYKFF EQMQN |
| Synonyms: | AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, preA4, CTFgamma, alpha-sAPP |
| Calculated MW: | 87kDa |
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