AMPKγ1 Polyclonal Antibody
- SKU:
- CAB22024
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | AMPKγ1 Polyclonal Antibody |
| Product Code: | CAB22024 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, K562, HeLa, Mouse kidney, Mouse lung, Rat kidney, Rat lung |
| Cellular Location: | cytoplasm, cytosol, nucleoplasm, nucleus |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human AMPKγ1 (NP_002724.1). |
| Sequence: | KSALV QIYEL EEHKI ETWRE VYLQD SFKPL VCISP NASLF DAVSS LIRNK IHRLP VIDPE SGNTL YILTH KRILK FLKLF ITEFP KPEFM SKSLE ELQIG T |
| Synonyms: | AMPKG |
| Calculated MW: | 38kDa |
| Observed MW: | 37kDa |
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