Alpha-Fetoprotein (AFP) Monoclonal Antibody (CAB22053)
- SKU:
- CAB22053
Description
| Product Name: | Alpha-Fetoprotein (AFP) Monoclonal Antibody |
| Product Code: | CAB22053 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54866 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HepG2 |
| Cellular Location: | Secreted |
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-609 of human Alpha-Fetoprotein (AFP) (NP_001125.1). |
| Sequence: | RTLHR NEYGI ASILD SYQCT AEISL ADLAT IFFAQ FVQEA TYKEV SKMVK DALTA IEKPT GDEQS SGCLE NQLPA FLEEL CHEKE ILEKY GHSDC CSQSE EGRHN CFLAH KKPTP ASIPL FQVPE PVTSC EAYEE DRETF MNKFI YEIAR RHPFL YAPTI LLWAA RYDKI IPSCC KAENA VECFQ TKAAT VTKEL RESSL LNQHA CAVMK NFGTR TFQAI TVTKL SQKFT KVNFT EIQKL VLDVA HVHEH CCRGD VLDCL QDGEK IMSYI CSQQD TLSNK ITECC KLTTL ERGQC IIHAE NDEKP EGLSP NLNRF LGDRD FNQFS SGEKN IFLAS FVHEY SRRHP QLAVS VILRV AKGYQ ELLEK CFQTE NPLEC QDKGE EELQK YIQES QALAK RSCGL FQKLG EYYLQ NAFLV AYTKK APQLT SSELM AITRK MAATA ATCCQ LSEDK LLACG EGAAD IIIGH LCIRH EMTPV NPGVG QCCTS SYANR RPCFS SLVVD ETYVP PAFSD DKFIF HKDLC QAQGV ALQTM KQEFL INLVK QKPQI TEEQL EAVIA DFSGL LEKCC QGQEQ EVCFA EEGQK LISKT RAALG V |
| Synonyms: | AFPD, FETA, HPAFP |
| Calculated MW: | 69kDa |
| Observed MW: | 65kDa |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Monoclonal Antibody |
Reactivity: |
Human |
Host Species: |
Rabbit |
Isotype: |
IgG |
Applications: |
WB |
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