Alpha-1 Antitrypsin (SERPINA1) Monoclonal Antibody
- SKU:
- CAB21972
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | Alpha-1 Antitrypsin (SERPINA1) Monoclonal Antibody |
| Product Code: | CAB21972 |
| Reactivity: | Human |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54184 |
| Reactivity: | Human |
| Tested Applications: | IF/ICC, ELISA |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Endoplasmic reticulum, Secreted, extracellular matrix, extracellular space |
The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-418 of human Alpha-1 Antitrypsin (SERPINA1) (NP_000286.3). |
| Sequence: | EDPQG DAAQK TDTSH HDQDH PTFNK ITPNL AEFAF SLYRQ LAHQS NSTNI FFSPV SIATA FAMLS LGTKA DTHDE ILEGL NFNLT EIPEA QIHEG FQELL RTLNQ PDSQL QLTTG NGLFL SEGLK LVDKF LEDVK KLYHS EAFTV NFGDT EEAKK QINDY VEKGT QGKIV DLVKE LDRDT VFALV NYIFF KGKWE RPFEV KDTEE EDFHV DQVTT VKVPM MKRLG MFNIQ HCKKL SSWVL LMKYL GNATA IFFLP DEGKL QHLEN ELTHD IITKF LENED RRSAS LHLPK LSITG TYDLK SVLGQ LGITK VFSNG ADLSG VTEEA PLKLS KAVHK AVLTI DEKGT EAAGA MFLEA IPMSI PPEVK FNKPF VFLMI EQNTK SPLFM GKVVN PTQK |
| Synonyms: | PI, A1A, AAT, PI1, A1AT, nNIF, PRO2275, alpha1AT |
| Calculated MW: | 47kDa |
| Observed MW: | Refer to figures |
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