ALOX5 Monoclonal Antibody
- SKU:
- CAB24617
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | ALOX5 Monoclonal Antibody |
| Product Code: | CAB24617 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC61510 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:1000-1:5000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Raji, U-2 OS, Mouse lung |
| Cellular Location: | Cytoplasm, Nucleus matrix, Nucleus membrane, Peripheral membrane protein |
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8, 11, 14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7, 9-trans-11, 14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ALOX5（NP_000689.1）. |
| Sequence: | MPSYT VTVAT GSQWF AGTDD YIYLS LVGSA GCSEK HLLDK PFYND FERGA VDSYD VTVDE ELGEI QLVRI EKRKY WLNDD WYLKY ITLKT PHGDY IEFPC |
| Synonyms: | 5-LO, 5LPG, LOG5, 5-LOX |
| Calculated MW: | 78kDa/71KDa/74KDa/61KDa/56KDa |
| Observed MW: | 71kDa |
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