Alkaline Phosphatase/ALPI Recombinant Protein (RPES4373)
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- SKU:
- RPES4373
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Alkaline Phosphatase/ALPI Recombinant Protein
ALPI encodes for intestinal phosphatase alkaline; a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI-based treatments in intestinal inflammatory disorders.
| Product Name: | Alkaline Phosphatase/ALPI Recombinant Protein (RPES4373) |
| Product Code: | RPES4373 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | IAP |
| Accession: | P09923 |
| Sequence: | Met 1-Asp 503 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to cleave a fluorogenic substrate; 4-Methylumbelliferyl phosphate (4-MUP).The specific activity is > 1;000 pmoles/min/µg. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mature form of human ALPI (P09923) (Met 1-Asp 503);without the pro peptide; was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 54 kDa |
| AP Mol Mass: | 66 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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