Alkaline Phosphatase/ALPI Recombinant Protein (RPES4373)

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SKU:
RPES4373
Product Type:
Recombinant Protein
Species:
Human

Description

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Alkaline Phosphatase/ALPI Recombinant Protein

ALPI encodes for intestinal phosphatase alkaline; a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI-based treatments in intestinal inflammatory disorders.

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