ALG6 Antibody (PACO19092)
- SKU:
- PACO19092
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ALG6 Antibody (PACO19092) |
| Antibody SKU: | PACO19092 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human ALG6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: PACO19092(ALG6 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
| Background: | This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. |
| Synonyms: | ALG6, alpha-1,3-glucosyltransferase |
| UniProt Protein Function: | ALG6: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. Defects in ALG6 are the cause of congenital disorder of glycosylation type 1C (CDG1C); also known as carbohydrate-deficient glycoprotein syndrome type V. CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1C patients have muscular hypotonia, show a delayed statomotor development and are mentally retarded. CDG1C is biochemically characterized by an accumulation of dolichyl pyrophosphate-linked Man(9)GlcNAc(2) in the endoplasmic reticulum. Belongs to the ALG6/ALG8 glucosyltransferase family.Protein type: Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; EC 2.4.1.267; Membrane protein, multi-pass; TransferaseChromosomal Location of Human Ortholog: 1p31.3Cellular Component: endoplasmic reticulum membrane; membraneMolecular Function: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity; glucosyltransferase activityBiological Process: dolichol-linked oligosaccharide biosynthetic process; oligosaccharide-lipid intermediate assembly; protein amino acid N-linked glycosylationDisease: Congenital Disorder Of Glycosylation, Type Ic |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y672 |
| NCBI GenInfo Identifier: | 21263380 |
| NCBI Gene ID: | 29929 |
| NCBI Accession: | Q9Y672.1 |
| UniProt Secondary Accession: | Q9Y672,Q5SXR9, Q9H3I0, B3KMU2 |
| UniProt Related Accession: | Q9Y672 |
| Molecular Weight: | 58,181 Da |
| NCBI Full Name: | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase |
| NCBI Synonym Full Names: | ALG6, alpha-1,3-glucosyltransferase |
| NCBI Official Symbol: | ALG6 |
| NCBI Official Synonym Symbols: | CDG1C |
| NCBI Protein Information: | dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase |
| UniProt Protein Name: | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase |
| UniProt Synonym Protein Names: | Asparagine-linked glycosylation protein 6 homolog; Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase |
| Protein Family: | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase |
| UniProt Gene Name: | ALG6 |
| UniProt Entry Name: | ALG6_HUMAN |
| Antibodies |
| ALG6 Antibody (PACO07698) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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