ALDH8A1 Antibody (PACO07691)
- SKU:
- PACO07691
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ALDH8A1 Antibody (PACO07691) |
| Antibody SKU: | PACO07691 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human ALDH8A1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | aldehyde dehydrogenase 8 family, member A1;ALDH8A1;ALDH12;DJ352A20.2;DKFZp779D2315;MGC138650 ; |
| UniProt Protein Function: | ALDH8A1: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). Belongs to the aldehyde dehydrogenase family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.2.1.-; Oxidoreductase Chromosomal Location of Human Ortholog: 6q23.2 Cellular Component: cytoplasm; intracellular Molecular Function:aldehyde dehydrogenase (NAD) activity; retinal dehydrogenase activity Biological Process: retinal metabolic process; 9-cis-retinoic acid biosynthetic process; retinoic acid metabolic process |
| NCBI Summary: | This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q9H2A2 |
| NCBI GenInfo Identifier: | 74752601 |
| NCBI Gene ID: | 64577 |
| NCBI Accession: | Q9H2A2.1 |
| UniProt Secondary Accession: | Q9H2A2,O60793, Q24JS9, Q53GT3, Q5TI80, B7Z521, |
| UniProt Related Accession: | Q9H2A2 |
| Molecular Weight: | 487 |
| NCBI Full Name: | Aldehyde dehydrogenase family 8 member A1 |
| NCBI Synonym Full Names: | aldehyde dehydrogenase 8 family, member A1 |
| NCBI Official Symbol: | ALDH8A1 |
| NCBI Official Synonym Symbols: | ALDH12; DJ352A20.2 |
| NCBI Protein Information: | aldehyde dehydrogenase family 8 member A1; aldehyde dehydrogenase 12; aldehyde dehydrogenase family protein |
| UniProt Protein Name: | Aldehyde dehydrogenase family 8 member A1 |
| UniProt Synonym Protein Names: | Aldehyde dehydrogenase 12 |
| Protein Family: | Aldehyde dehydrogenase family |
| UniProt Gene Name: | ALDH8A1 |
| UniProt Entry Name: | AL8A1_HUMAN |
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