AKAP7 Antibody (PACO15357)
- SKU:
- PACO15357
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | AKAP7 Antibody (PACO15357) |
| Antibody SKU: | PACO15357 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human AKAP7 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15357(AKAP7 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human bladder carcinoma tissue, Primary antibody: PACO15357(AKAP7 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15357(AKAP7 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. |
| Synonyms: | A kinase (PRKA) anchor protein 7 |
| UniProt Protein Function: | AKAP7 iso1: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 6q23.2 Cellular Component: cytosol Molecular Function:protein binding; protein kinase A binding Biological Process: protein localization |
| NCBI Summary: | This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011] |
| UniProt Code: | O43687 |
| NCBI GenInfo Identifier: | 25108878 |
| NCBI Gene ID: | 9465 |
| NCBI Accession: | O43687.4 |
| UniProt Secondary Accession: | O43687,Q5TBR9, Q5TBS0, Q9HCZ8, Q9P0G4, A8K2K6, |
| UniProt Related Accession: | Q9P0M2,O43687 |
| Molecular Weight: | 11kDa |
| NCBI Full Name: | A-kinase anchor protein 7 isoforms alpha and beta |
| NCBI Synonym Full Names: | A-kinase anchoring protein 7 |
| NCBI Official Symbol: | AKAP7 |
| NCBI Official Synonym Symbols: | AKAP15; AKAP18 |
| NCBI Protein Information: | A-kinase anchor protein 7 isoform gamma; A-kinase anchor protein 7 |
| UniProt Protein Name: | A-kinase anchor protein 7 isoforms alpha and beta |
| UniProt Synonym Protein Names: | A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta; PRKA7 isoforms alpha/beta |
| Protein Family: | A-kinase anchor protein |
| UniProt Gene Name: | AKAP7 |
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