Aif1 Antibody (PACO24823)
- SKU:
- PACO24823
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Aif1 Antibody (PACO24823) |
| Antibody SKU: | PACO24823 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Allograft inflammatory factor 1 protein (2-147AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Aif1 antibody at 2µg/ml + THP-1 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 17 kDa Observed band size: 17 kDa . |
| Background: | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Synonyms: | Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1), Aif1, Iba1 |
| UniProt Protein Function: | AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalCellular Component: actin filament; cell projection; cytoplasm; cytoskeleton; cytosol; lamellipodium; membrane; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup; plasma membrane; ruffleMolecular Function: actin binding; actin filament binding; calcium ion binding; metal ion binding; protein bindingBiological Process: actin filament bundle formation; actin filament polymerization; microglial cell activation; negative regulation of apoptosis; negative regulation of smooth muscle cell proliferation; phagocytosis, engulfment; positive regulation of cell migration; positive regulation of muscle hyperplasia; positive regulation of nitric oxide biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; Rac protein signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O70200 |
| NCBI GenInfo Identifier: | 9506379 |
| NCBI Gene ID: | 11629 |
| NCBI Accession: | NP_062340.1 |
| UniProt Secondary Accession: | O70200 |
| UniProt Related Accession: | O70200 |
| Molecular Weight: | 16,911 Da |
| NCBI Full Name: | allograft inflammatory factor 1 |
| NCBI Synonym Full Names: | allograft inflammatory factor 1 |
| NCBI Official Symbol: | Aif1 |
| NCBI Official Synonym Symbols: | G1; Iba1; AIF-1; AI607846; D17H6S50E |
| NCBI Protein Information: | allograft inflammatory factor 1 |
| UniProt Protein Name: | Allograft inflammatory factor 1 |
| UniProt Synonym Protein Names: | Ionized calcium-binding adapter molecule 1 |
| Protein Family: | Apoptosis-inducing factor |
| UniProt Gene Name: | Aif1 |
| UniProt Entry Name: | AIF1_MOUSE |
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