AIF Polyclonal Antibody

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SKU:
CAB0811
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC
Applications:
IF

Description

Product Name:AIF Polyclonal Antibody
Product Code:CAB0811
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples:HepG2
Cellular Location:Cytoplasm, Mitochondrion inner membrane, Mitochondrion intermembrane space, Nucleus, perinuclear region

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 334-613 of human AIF (NP_004199.1).
Sequence:FPEKG NMGKI LPEYL SNWTM EKVRR EGVKV MPNAI VQSVG VSSGK LLIKL KDGRK VETDH IVAAV GLEPN VELAK TGGLE IDSDF GGFRV NAELQ ARSNI WVAGD AACFY DIKLG RRRVE HHDHA VVSGR LAGEN MTGAA KPYWH QSMFW SDLGP DVGYE AIGLV DSSLP TVGVF AKATA QDNPK SATEQ SGTGI RSESE TESEA SEITI PPSTP AVPQA PVQGE DYGKG VIFYL RDKVV VGIVL WNIFN RMPIA RKIIK DGEQH EDLNE VAKLF NIHED
Synonyms:AIF, AUNX1, CMT2D, CMTX4, COWCK, DFNX5, NADMR, NAMSD, PDCD8, COXPD6, SEMDHL
Calculated MW:67kDa
Observed MW:60kDa
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