AIDA Antibody (PACO63839)
- SKU:
- PACO63839
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | AIDA Antibody (PACO63839) |
| Antibody SKU: | PACO63839 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Axin interactor, dorsalization-associated protein (14-306AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of U251 cells with PACO63839 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). |
| Synonyms: | Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist), AIDA, C1orf80 |
| UniProt Protein Function: | AIDA: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling. Belongs to the AIDA family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cell development/differentiationChromosomal Location of Human Ortholog: 1q41Molecular Function: protein bindingBiological Process: dorsal/ventral pattern formation; negative regulation of JNK activity; negative regulation of JNK cascade; regulation of protein homodimerization activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96BJ3 |
| NCBI GenInfo Identifier: | 74751770 |
| NCBI Gene ID: | 64853 |
| NCBI Accession: | Q96BJ3.1 |
| UniProt Secondary Accession: | Q96BJ3,Q49A81, Q5JRA4, Q658P1, Q9H9E8, A8K1F0 |
| UniProt Related Accession: | Q96BJ3 |
| Molecular Weight: | 25,914 Da |
| NCBI Full Name: | Axin interactor, dorsalization-associated protein |
| NCBI Synonym Full Names: | axin interactor, dorsalization associated |
| NCBI Official Symbol: | AIDA |
| NCBI Official Synonym Symbols: | C1orf80 |
| NCBI Protein Information: | axin interactor, dorsalization-associated protein |
| UniProt Protein Name: | Axin interactor, dorsalization-associated protein |
| UniProt Synonym Protein Names: | Axin interaction partner and dorsalization antagonist |
| Protein Family: | AIDA-I autotransporter |
| UniProt Gene Name: | AIDA |
| UniProt Entry Name: | AIDA_HUMAN |
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