AICDA Antibody (PACO20932)

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SKU:
PACO20932
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Applications:
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

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Antibody Name:AICDA Antibody (PACO20932)
Antibody SKU:PACO20932
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human AICDA
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20932(AICDA Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
Synonyms:activation-induced cytidine deaminase
UniProt Protein Function:AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.
UniProt Protein Details:

Protein type:EC 3.5.4.38; Hydrolase

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; exosome (RNase complex); nucleus

Molecular Function:protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity

Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing

Disease: Immunodeficiency With Hyper-igm, Type 2

NCBI Summary:This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
UniProt Code:Q9GZX7
NCBI GenInfo Identifier:23813666
NCBI Gene ID:57379
NCBI Accession:Q9GZX7.1
UniProt Related Accession:Q9GZX7
Molecular Weight:
NCBI Full Name:Single-stranded DNA cytosine deaminase
NCBI Synonym Full Names:activation induced cytidine deaminase
NCBI Official Symbol:AICDA  
NCBI Official Synonym Symbols:AID; ARP2; CDA2; HIGM2; HEL-S-284  
NCBI Protein Information:single-stranded DNA cytosine deaminase
UniProt Protein Name:Single-stranded DNA cytosine deaminase
UniProt Synonym Protein Names:Activation-induced cytidine deaminase; Cytidine aminohydrolase
Protein Family:AIDA-I autotransporter
UniProt Gene Name:AICDA  
UniProt Entry Name:AICDA_HUMAN
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Anti-AICDA Antibody (CAB12372)
AICDA Antibody (PACO02231)
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