Agxt Antibody (PACO24811)
- SKU:
- PACO24811
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Agxt Antibody (PACO24811) |
| Antibody SKU: | PACO24811 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Serine--pyruvate aminotransferase, mitochondrial protein (25-414AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). |
| Synonyms: | Serine--pyruvate aminotransferase, mitochondrial (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44), Agxt, Agxt1 |
| UniProt Protein Function: | AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.44; Motility/polarity/chemotaxis; Transferase; EC 2.6.1.51; Mitochondrial; Amino Acid Metabolism - glycine, serine and threonineCellular Component: mitochondrial matrix; mitochondrion; peroxisomal matrix; peroxisomeMolecular Function: alanine-glyoxylate transaminase activity; amino acid binding; catalytic activity; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity; transferase activityBiological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O35423 |
| NCBI GenInfo Identifier: | 111038130 |
| NCBI Gene ID: | 11611 |
| NCBI Accession: | NP_057911.2 |
| UniProt Secondary Accession: | O35423,Q8R128 |
| UniProt Related Accession: | O35423 |
| Molecular Weight: | 45.3 kDa |
| NCBI Full Name: | serine--pyruvate aminotransferase, mitochondrial isoform 1 |
| NCBI Synonym Full Names: | alanine-glyoxylate aminotransferase |
| NCBI Official Symbol: | Agxt |
| NCBI Official Synonym Symbols: | AGT; SPT; Agt1; Agxt1 |
| NCBI Protein Information: | serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal |
| UniProt Protein Name: | Serine--pyruvate aminotransferase, mitochondrial |
| UniProt Synonym Protein Names: | Alanine--glyoxylate aminotransferase (EC:2.6.1.44); AGT |
| Protein Family: | Serine--pyruvate aminotransferase |
| UniProt Gene Name: | Agxt |
| UniProt Entry Name: | SPYA_MOUSE |
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