Antibody Name:	AGR3 Antibody (PACO15351)
Antibody SKU:	PACO15351
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human AGR3

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15351(AGR3 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-2: MCF7 cells, human colon tissue, Primary antibody: PACO15351(AGR3 Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15351(AGR3 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).

Background:

Anterior gradient protein 3 homolog is a protein that in humans is encoded by the AGR3 gene. The deduced 166-amino acid, protein has an N-terminal signal sequence. Fluorescence-tagged BCMP11 localized in secretory or endosome-like organelles in transfected breast carcinoma cell lines. Immunohistochemical analysis showed that expression of BCMP11 was restricted in normal tissues, with significant staining of only the epithelial lining of colonic mucosa. However, BCMP11 was detected in 43 of 58 (74%) breast cancer tissues tested, but not in normal breast ductal epithelial cells. In cancerous epithelial cells, BCMP11 localized to the cytoplasm.

Synonyms:

Anterior gradient 3 homolog (Xenopus laevis)

UniProt Protein Function:	AGR3: Belongs to the AGR family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 7p21.1Cellular Component: extracellular regionMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q8TD06
NCBI GenInfo Identifier:	28827801
NCBI Gene ID:	155465
NCBI Accession:	NP_789783.1
UniProt Secondary Accession:	Q8TD06,A4D120
UniProt Related Accession:	Q8TD06
Molecular Weight:	19,171 Da
NCBI Full Name:	anterior gradient protein 3 homolog
NCBI Synonym Full Names:	anterior gradient 3 homolog (Xenopus laevis)
NCBI Official Symbol:	AGR3
NCBI Official Synonym Symbols:	AG3; HAG3; hAG-3; BCMP11; PDIA18
NCBI Protein Information:	anterior gradient protein 3 homolog; AG-3; anterior gradient homolog 3; breast cancer membrane protein 11; protein disulfide isomerase family A, member 18
UniProt Protein Name:	Anterior gradient protein 3 homolog
UniProt Synonym Protein Names:	Breast cancer membrane protein 11
Protein Family:	Anterior gradient protein
UniProt Gene Name:	AGR3
UniProt Entry Name:	AGR3_HUMAN