AGO4 Antibody (PACO19148)
- SKU:
- PACO19148
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | AGO4 Antibody (PACO19148) |
| Antibody SKU: | PACO19148 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human AGO4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19148(AGO4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. |
| Synonyms: | argonaute RISC catalytic component 4 |
| UniProt Protein Function: | AGO4: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Belongs to the argonaute family. Ago subfamily.Protein type: Translation; Translation initiationChromosomal Location of Human Ortholog: 1p34Cellular Component: cytoplasm; cytosol; membraneMolecular Function: double-stranded RNA binding; miRNA binding; protein binding; single-stranded RNA bindingBiological Process: miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; miRNA-mediated gene silencing, production of miRNAs; mRNA catabolic process; phosphoinositide-mediated signaling; pre-microRNA processing; RNA secondary structure unwinding; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HCK5 |
| NCBI GenInfo Identifier: | 29029593 |
| NCBI Gene ID: | 192670 |
| NCBI Accession: | NP_060099.2 |
| UniProt Secondary Accession: | Q9HCK5,A7MD27 |
| UniProt Related Accession: | Q9HCK5 |
| Molecular Weight: | 97,097 Da |
| NCBI Full Name: | protein argonaute-4 |
| NCBI Synonym Full Names: | argonaute 4, RISC catalytic component |
| NCBI Official Symbol: | AGO4 |
| NCBI Official Synonym Symbols: | EIF2C4 |
| NCBI Protein Information: | protein argonaute-4 |
| UniProt Protein Name: | Protein argonaute-4 |
| UniProt Synonym Protein Names: | Argonaute RISC catalytic component 4; Eukaryotic translation initiation factor 2C 4 |
| Protein Family: | Protein argonaute |
| UniProt Gene Name: | AGO4 |
| UniProt Entry Name: | AGO4_HUMAN |
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