Antibody Name:	AGBL2 Antibody (PACO36602)
Antibody SKU:	PACO36602
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Recombinant Human Cytosolic carboxypeptidase 2 protein (10-270AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot. All lanes: AGBL2 antibody at 8µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 105, 50, 33 kDa. Observed band size: 105 kDa.
	Immunohistochemistry of paraffin-embedded human colon cancer using PACO36602 at dilution of 1:100.
	Immunohistochemistry of paraffin-embedded human breast cancer using PACO36602 at dilution of 1:100.

Background:

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.

Synonyms:

Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2), AGBL2, CCP2

UniProt Protein Function:	AGBL2: Metallocarboxypeptidase that may play a role in the processing of tubulin. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.17.-; ProteaseChromosomal Location of Human Ortholog: 11p11.2Cellular Component: centriole; cytosolMolecular Function: zinc ion binding; metallocarboxypeptidase activityBiological Process: proteolysis
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q5U5Z8
NCBI GenInfo Identifier:	31657119
NCBI Gene ID:	79841
NCBI Accession:	NP_079059.2
UniProt Secondary Accession:	Q5U5Z8,Q53FV5, Q8IV57, Q9H5C0, A8MPX2
UniProt Related Accession:	Q5U5Z8
Molecular Weight:	104,194 Da
NCBI Full Name:	cytosolic carboxypeptidase 2
NCBI Synonym Full Names:	ATP/GTP binding protein-like 2
NCBI Official Symbol:	AGBL2
NCBI Official Synonym Symbols:
NCBI Protein Information:	cytosolic carboxypeptidase 2
UniProt Protein Name:	Cytosolic carboxypeptidase 2
UniProt Synonym Protein Names:	ATP/GTP-binding protein-like 2
Protein Family:	Cysteine proteinase
UniProt Gene Name:	AGBL2
UniProt Entry Name:	CBPC2_HUMAN