Antibody Name:	AGBL2 Antibody (PACO15341)
Antibody SKU:	PACO15341
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Fusion protein of human AGBL2

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15341(AGBL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15341(AGBL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).

Background:

Metallocarboxypeptidase that may play a role in the processing of tubulin. Knockdown of AGBL2 results in a failure of the cell to detyrosinate the C-terminal EEY region of α -tubulin and indicates that, it is a candidate for the long sought after tubulin tyrosine carboxypeptidase important in regulation of microtubule dynamics. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis and identify a novel area for therapeutic intervention.

Synonyms:

ATP/GTP binding protein-like 2

UniProt Protein Function:	AGBL2: Metallocarboxypeptidase that may play a role in the processing of tubulin. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.17.-; ProteaseChromosomal Location of Human Ortholog: 11p11.2Cellular Component: centriole; cytosolMolecular Function: zinc ion binding; metallocarboxypeptidase activityBiological Process: proteolysis
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q5U5Z8
NCBI GenInfo Identifier:	31657119
NCBI Gene ID:	79841
NCBI Accession:	NP_079059.2
UniProt Secondary Accession:	Q5U5Z8,Q53FV5, Q8IV57, Q9H5C0, A8MPX2
UniProt Related Accession:	Q5U5Z8
Molecular Weight:	104,194 Da
NCBI Full Name:	cytosolic carboxypeptidase 2
NCBI Synonym Full Names:	ATP/GTP binding protein-like 2
NCBI Official Symbol:	AGBL2
NCBI Official Synonym Symbols:
NCBI Protein Information:	cytosolic carboxypeptidase 2
UniProt Protein Name:	Cytosolic carboxypeptidase 2
UniProt Synonym Protein Names:	ATP/GTP-binding protein-like 2
Protein Family:	Cysteine proteinase
UniProt Gene Name:	AGBL2
UniProt Entry Name:	CBPC2_HUMAN