AGBL1 Antibody (PACO18528)
- SKU:
- PACO18528
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | AGBL1 Antibody (PACO18528) |
| Antibody SKU: | PACO18528 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:15-1:50 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human AGBL1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18528(AGBL1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18528(AGBL1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. |
| Synonyms: | ATP/GTP binding protein-like 1 |
| UniProt Protein Function: | Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. |
| UniProt Protein Details: | |
| NCBI Summary: | Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013] |
| UniProt Code: | Q96MI9 |
| NCBI GenInfo Identifier: | 158706472 |
| NCBI Gene ID: | 123624 |
| NCBI Accession: | Q96MI9.2 |
| UniProt Secondary Accession: | Q96MI9,A1A4X5, A6NJH6, C9JHL5 |
| UniProt Related Accession: | Q96MI9 |
| Molecular Weight: | 90,789 Da |
| NCBI Full Name: | Cytosolic carboxypeptidase 4 |
| NCBI Synonym Full Names: | ATP/GTP binding protein like 1 |
| NCBI Official Symbol: | AGBL1 |
| NCBI Official Synonym Symbols: | CCP4; FECD8 |
| NCBI Protein Information: | cytosolic carboxypeptidase 4 |
| UniProt Protein Name: | Cytosolic carboxypeptidase 4 |
| UniProt Synonym Protein Names: | ATP/GTP-binding protein-like 1 |
| Protein Family: | Cytosolic carboxypeptidase |
| UniProt Gene Name: | AGBL1 |
| UniProt Entry Name: |
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