AF/LE Purified Mouse CD279/PD-1 Monoclonal Antibody [29F.1A12](AGEL1624)

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SKU:
AGEL1624
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC

Description

Antibody Name:AF/LE Purified Mouse CD279/PD-1 Monoclonal Antibody
Antibody Code:AGEL1624
Size:500µg
Clone:29F.1A12
Synonyms:PD-1, Programmed Death-1
Host Species:Rat
Species Reactivity:Mouse
Applications:Block, Neut, FC, WB, IHC, IF
Concentration:1mg/mL
Isotype:IgG2a,k
Conjugation:Azide Free/Low endotoxin
Applications:Block, Neut, FC, WB, IHC, IF
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:0.2 µm filtered in PBS, pH7.2. Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg (< 0.002EU/µg) as Determined by LAL gel clotting assay. Purity is > 95% as determined by SDS-PAGE
Storage:Store at 2-8°C. Do not freeze.
Gene ID:18566
Uniprot:Q02242
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
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