](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/12373/16425/afle-purified-mouse-cd115-monoclonal-antibody-afs98agel1365__02761__91826.1706269996.jpg?c=1?imbypass=on "AF/LE Purified Mouse CD115 Monoclonal Antibody [AFS98](AGEL1365)")
Description
| Antibody Name: | AF/LE Purified Mouse CD115 Monoclonal Antibody |
| Antibody Code: | AGEL1365 |
| Size: | 500µg |
| Clone: | AFS98 |
| Synonyms: | Macrophage colony-stimulating factor 1 receptor,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115,Csf1r,Csfmr,Fms |
| Host Species: | Rat |
| Species Reactivity: | Mouse |
| Applications: | Block, Depletion, Neut, FC, WB |
| Concentration: | 1mg/mL |
| Isotype: | IgG2a,k |
| Conjugation: | Azide Free/Low endotoxin |
| Applications: | Block, Depletion, Neut, FC, WB |
| Recommended Dilution: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Storage Buffer: | PBS, PH7.2 |
| Storage: | Store at 2-8°C. Do not freeze. |
| Gene ID: | 12978 |
| Uniprot: | P09581 |
| Background: | CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. |
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