Description
Antibody Name: | AF/LE Purified Human IL-4 Monoclonal Antibody |
Antibody Code: | AGEL2053 |
Size: | 500µg |
Clone: | MP4-25D2 |
Synonyms: | Interleukin-4,IL-4,B-cell IgG differentiation factor,B-cell growth factor 1,BSF-1,IGG1 induction factor |
Host Species: | Rat |
Species Reactivity: | Human |
Applications: | Neut, FC, IHC |
Concentration: | 1mg/mL |
Isotype: | IgG2a,k |
Conjugation: | Azide Free/Low endotoxin |
Applications: | Neut, FC, IHC |
Recommended Dilution: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Storage Buffer: | 0.2 µm filtered in PBS, pH7.2. Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg (< 0.002EU/µg) as Determined by LAL gel clotting assay. Purity is > 95% as determined by SDS-PAGE |
Storage: | Store at 2-8°C. Do not freeze. |
Gene ID: | 3565 |
Uniprot: | P05112 |
Background: | IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |