AF/LE Purified Human CD279/PD-1 Monoclonal Antibody [J116](AGEL1606)

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SKU:
AGEL1606
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC

Description

Antibody Name:AF/LE Purified Human CD279/PD-1 Monoclonal Antibody
Antibody Code:AGEL1606
Size:500µg
Clone:J116
Synonyms:PD-1, Programmed Death-1
Host Species:Mouse
Species Reactivity:Human
Applications:Block, Neut, FC, IHC, IP
Concentration:1mg/mL
Isotype:IgG2a,k
Conjugation:Azide Free/Low endotoxin
Applications:Block, Neut, FC, IHC, IP
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:0.2 µm filtered in PBS, pH7.2. Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg (< 0.002EU/µg) as Determined by LAL gel clotting assay. Purity is > 95% as determined by SDS-PAGE
Storage:Store at 2-8°C. Do not freeze.
Gene ID:5133
Uniprot:Q15116
Background:Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
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