AF/LE Purified Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

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SKU:
AGEL2259
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Applications:
Block
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2b, κ
Clone:
10F.9G2
Conjugation:
None (Low endotoxin)

Description

Product Name:AF/LE Purified Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
Product Code:AGEL2259
Clone No:10F.9G2
Synonyms:B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Reactivity:Mouse
Host Species:Rat
Applications:FCM, Block
Isotype:Rat IgG2b, κ
Isotype Control:APC Armenian Hamster IgG Isotype Control [PIP] (AGEL2691)
Conjugation:None (Purified antibody-Azide Free/Low endotoxin)
Form:Liquid
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Swissprot:Q9EP73
Stability & Storage:Keep as concentrated solution. Store at 2-8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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