AF/LE Purified Anti-Mouse CD119 Antibody [GR-20]
- SKU:
- AGEL2218
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- Rat IgG2a, κ
- Clone:
- GR-20
- Conjugation:
- None (Low endotoxin)
Description
| Product Name: | AF/LE Purified Anti-Mouse CD119 Antibody [GR-20] |
| Product Code: | AGEL2218 |
| Clone No: | GR-20 |
| Synonyms: | Interferon gamma receptor 1,Ifngr1,IFN-gamma-R1,IFN-gamma-R-alpha,CD119 |
| Reactivity: | Mouse |
| Host Species: | Rat |
| Applications: | FCM |
| Isotype: | Rat IgG2a, κ |
| Isotype Control: | Low Endotoxin Purified Rat IgG2a, κ Isotype Control [2A3] (AGEL2652) |
| Conjugation: | None (Purified antibody-Azide Free/Low endotoxin) |
| Form: | Liquid |
| Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Storage Buffer: | 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
| Swissprot: | P15261 |
| Stability & Storage: | Keep as concentrated solution. Store at 2-8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Shipping: | Biological ice pack at 4°C |
CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.
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