ADM2 Antibody (PACO17492)
- SKU:
- PACO17492
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ADM2 Antibody (PACO17492) |
| Antibody SKU: | PACO17492 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human ADM2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO17492(ADM2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17492(ADM2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
| Synonyms: | adrenomedullin 2 |
| UniProt Protein Function: | ADM2: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. Belongs to the adrenomedullin family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 22q13.33Cellular Component: extracellular regionMolecular Function: protein complex bindingBiological Process: angiogenesis; positive regulation of angiogenesis; protein amino acid phosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q7Z4H4 |
| NCBI GenInfo Identifier: | 47115749 |
| NCBI Gene ID: | 79924 |
| NCBI Accession: | Q7Z4H4.1 |
| UniProt Secondary Accession: | Q7Z4H4,Q3LFQ0 |
| UniProt Related Accession: | Q7Z4H4 |
| Molecular Weight: | 15,865 Da |
| NCBI Full Name: | ADM2 |
| NCBI Synonym Full Names: | adrenomedullin 2 |
| NCBI Official Symbol: | ADM2 |
| NCBI Official Synonym Symbols: | AM2; dJ579N16.4 |
| NCBI Protein Information: | ADM2 |
| UniProt Protein Name: | ADM2 |
| UniProt Synonym Protein Names: | Intermedin |
| Protein Family: | ADM |
| UniProt Gene Name: | ADM2 |
| UniProt Entry Name: | ADM2_HUMAN |
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