| Background: | Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid, combustion. Antagonizes TNF-α by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. |
| Synonyms: | Adiponectin (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte, C1q and collagen domain-containing protein) (Adipose most abundant gene transcript 1 protein) (apM-1), ADIPOQ, ACRP30 APM1 |
| UniProt Protein Function: | Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q3Y5Z3 |
| NCBI GenInfo Identifier: | 27807433 |
| NCBI Gene ID: | 282865 |
| NCBI Accession: | NP_777167.1 |
| UniProt Secondary Accession: | Q3Y5Z3,Q95MQ4, A5D7A8 |
| UniProt Related Accession: | Q3Y5Z3 |
| Molecular Weight: | 26,133 Da |
| NCBI Full Name: | adiponectin |
| NCBI Synonym Full Names: | adiponectin, C1Q and collagen domain containing |
| NCBI Official Symbol: | ADIPOQ |
| NCBI Official Synonym Symbols: | APM1; ACRP30 |
| NCBI Protein Information: | adiponectin |
| UniProt Protein Name: | Adiponectin |
| UniProt Synonym Protein Names: | 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte, C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; apM-1 |
| Protein Family: | |
| UniProt Gene Name: | ADIPOQ |
| UniProt Entry Name: | |
