Name: Adh7 Antibody (PACO36378)
SKU: PACO36378
Availability: OutOfStock

Antibody Name:	Adh7 Antibody (PACO36378)
Antibody SKU:	PACO36378
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:	Mouse
Immunogen:	Recombinant Mouse Alcohol dehydrogenase class 4 mu/sigma chain protein (1-374AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western Blot. Positive WB detected in: Mouse liver tissue. All lanes: Adh7 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40 kDa. Observed band size: 40 kDa.

Background:	Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation.
Synonyms:	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (ADH-C2) (Alcohol dehydrogenase 7) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Retinol dehydrogenase), Adh7, Adh-3 Adh3

UniProt Protein Function:	ADH7: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase; Lipid Metabolism - fatty acid; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.1Cellular Component: cytoplasm; extracellular region; intracellularMolecular Function: alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; aldehyde oxidase activity; ethanol binding; metal ion binding; NAD binding; oxidoreductase activity; protein homodimerization activity; receptor antagonist activity; retinol binding; retinol dehydrogenase activity; zinc ion bindingBiological Process: ethanol catabolic process; ethanol metabolic process; ethanol oxidation; fatty acid omega-oxidation; response to bacterium; response to ethanol; retinoic acid metabolic process; retinoid metabolic process; retinol metabolic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q64437
NCBI GenInfo Identifier:	31560625
NCBI Gene ID:	11529
NCBI Accession:	NP_033756.2
UniProt Secondary Accession:	Q64437
UniProt Related Accession:	Q64437
Molecular Weight:	55.9 kDa
NCBI Full Name:	alcohol dehydrogenase class 4 mu/sigma chain
NCBI Synonym Full Names:	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
NCBI Official Symbol:	Adh7
NCBI Official Synonym Symbols:	Adh3; Adh4; Adh-3; Adt-1; Adh-3e; Adh-3t; Adh3-e; Adh3-t; AI325182
NCBI Protein Information:	alcohol dehydrogenase class 4 mu/sigma chain
UniProt Protein Name:	Alcohol dehydrogenase class 4 mu/sigma chain
UniProt Synonym Protein Names:	ADH-C2; Alcohol dehydrogenase 7; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase
Protein Family:	Alcohol dehydrogenase
UniProt Gene Name:	Adh7
UniProt Entry Name:	ADH7_MOUSE