ADGRA2 Antibody (PACO54554)
- SKU:
- PACO54554
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ADGRA2 Antibody (PACO54554) |
| Antibody SKU: | PACO54554 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human Adhesion G protein-coupled receptor A2 protein (1069-1338AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: A549 whole cell lysate, Rat heart tissue. All lanes: ADGRA2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 143, 120, 20 kDa. Observed band size: 143, 120 kDa. |
 | Immunofluorescent analysis of HepG2 cells using PACO54554 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO54554 at dilution of 1:100. |
| Background: | Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate. |
| Synonyms: | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5), ADGRA2, GPR124 KIAA1531 TEM5 |
| UniProt Protein Function: | GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 8p11.23Cellular Component: cell surface; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; regulation of chemotaxis; central nervous system development; endothelial cell migration; sprouting angiogenesis; regulation of angiogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96PE1 |
| NCBI GenInfo Identifier: | 221222450 |
| NCBI Gene ID: | 25960 |
| NCBI Accession: | Q96PE1.2 |
| UniProt Secondary Accession: | Q96PE1,Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4, A6H8W3 D3DSW4 |
| UniProt Related Accession: | Q96PE1 |
| Molecular Weight: | 19,530 Da |
| NCBI Full Name: | G-protein coupled receptor 124 |
| NCBI Synonym Full Names: | G protein-coupled receptor 124 |
| NCBI Official Symbol: | GPR124 |
| NCBI Official Synonym Symbols: | TEM5 |
| NCBI Protein Information: | G-protein coupled receptor 124; tumor endothelial marker 5 |
| UniProt Protein Name: | G-protein coupled receptor 124 |
| UniProt Synonym Protein Names: | Tumor endothelial marker 5 |
| Protein Family: | |
| UniProt Gene Name: | GPR124 |
| UniProt Entry Name: | GP124_HUMAN |
| Antibodies | ELISA Kits |
| GPR124 Antibody (PACO03806) | Human GPR124 (G Protein Coupled Receptor 124) ELISA Kit (HUFI03421) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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