| UniProt Protein Function: | ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Adenylyl cyclase; Nucleotide Metabolism - purine; Transporter, aquaporin family; EC 4.6.1.1; Transporter; Membrane protein, integral; LyaseChromosomal Location of Human Ortholog: 3q21.1Cellular Component: integral to membrane; plasma membraneMolecular Function: adenylate cyclase activity; adenylate cyclase binding; protein heterodimerization activityBiological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; renal water homeostasisDisease: Dyskinesia, Familial, With Facial Myokymia |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | O95622 |
| NCBI GenInfo Identifier: | 118572619 |
| NCBI Gene ID: | 111 |
| NCBI Accession: | O95622.3 |
| UniProt Secondary Accession: | O95622,Q7RTV7, Q8NFM3, B7Z8A6 |
| UniProt Related Accession: | O95622 |
| Molecular Weight: | 102,606 Da |
| NCBI Full Name: | Adenylate cyclase type 5 |
| NCBI Synonym Full Names: | adenylate cyclase 5 |
| NCBI Official Symbol: | ADCY5 |
| NCBI Official Synonym Symbols: | AC5; FDFM |
| NCBI Protein Information: | adenylate cyclase type 5 |
| UniProt Protein Name: | Adenylate cyclase type 5 |
| UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5 |
| Protein Family: | Adenylate cyclase |
| UniProt Gene Name: | ADCY5 |
| UniProt Entry Name: | ADCY5_HUMAN |
