Antibody Name:	ADAMTS17 Antibody (PACO19063)
Antibody SKU:	PACO19063
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human ADAMTS17

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19063(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: PACO19063(ADAMTS17 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 hour.
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19063(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined.

Synonyms:

ADAM metallopeptidase with thrombospondin type 1 motif, 17

UniProt Protein Function:	ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.24.-; Secreted; Secreted, signal peptide; Protease; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q24Disease: Weill-marchesani-like Syndrome
UniProt Protein Details:
NCBI Summary:	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
UniProt Code:	Q8TE56
NCBI GenInfo Identifier:	296434401
NCBI Gene ID:	170691
NCBI Accession:	Q8TE56.2
UniProt Secondary Accession:	Q8TE56,Q2I7G4, Q6ZN75
UniProt Related Accession:	Q8TE56
Molecular Weight:	54,757 Da
NCBI Full Name:	A disintegrin and metalloproteinase with thrombospondin motifs 17
NCBI Synonym Full Names:	ADAM metallopeptidase with thrombospondin type 1 motif 17
NCBI Official Symbol:	ADAMTS17
NCBI Official Synonym Symbols:
NCBI Protein Information:	A disintegrin and metalloproteinase with thrombospondin motifs 17
UniProt Protein Name:	A disintegrin and metalloproteinase with thrombospondin motifs 17
UniProt Synonym Protein Names:
Protein Family:	A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:	ADAMTS17
UniProt Entry Name:	ATS17_HUMAN