ADAMTS17 Antibody (PACO03573)
- SKU:
- PACO03573
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ADAMTS17 Antibody |
| Antibody SKU: | PACO03573 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human ADAMTS-17. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ADAMTS17; A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM-TS 17; ADAM-TS17; ADAMTS-17 |
| UniProt Protein Function: | ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.24.-; Secreted; Secreted, signal peptide; Protease; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q24Disease: Weill-marchesani-like Syndrome |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016] |
| UniProt Code: | Q8TE56 |
| NCBI GenInfo Identifier: | 296434401 |
| NCBI Gene ID: | 170691 |
| NCBI Accession: | Q8TE56.2 |
| UniProt Secondary Accession: | Q8TE56,Q2I7G4, Q6ZN75 |
| UniProt Related Accession: | Q8TE56 |
| Molecular Weight: | 54,757 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 17 |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 17 |
| NCBI Official Symbol: | ADAMTS17 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 17 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 17 |
| UniProt Synonym Protein Names: | |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS17 |
| UniProt Entry Name: | ATS17_HUMAN |
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