ADAMTS14 Antibody (PACO19058)
- SKU:
- PACO19058
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ADAMTS14 Antibody (PACO19058) |
| Antibody SKU: | PACO19058 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human ADAMTS14 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19058(ADAMTS14 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. |
| Synonyms: | ADAM metallopeptidase with thrombospondin type 1 motif, 14 |
| UniProt Protein Function: | Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016] |
| UniProt Code: | Q8WXS8 |
| NCBI GenInfo Identifier: | 21265052 |
| NCBI Gene ID: | 140766 |
| NCBI Accession: | NP_542453.2 |
| UniProt Secondary Accession: | Q8WXS8,Q5T4G0, Q5T4G1, Q8TE55, Q8TEY8 |
| UniProt Related Accession: | Q8WXS8 |
| Molecular Weight: | 134 |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform 2 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 14 |
| NCBI Official Symbol: | ADAMTS14 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 14 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 14 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | ADAMTS14 |
| UniProt Entry Name: |
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