ADAMTS12 Antibody (PACO05429)
- SKU:
- PACO05429
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ADAMTS12 Antibody (PACO05429) |
| Antibody SKU: | PACO05429 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:20000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the Internal region of human ADAMTS-12. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ADAMTS12; A disintegrin and metalloproteinase with thrombospondin motifs 12; ADAM-TS 12; ADAM-TS12; ADAMTS-12 |
| UniProt Protein Function: | ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Protease Chromosomal Location of Human Ortholog: 5q35 Cellular Component: extracellular matrix; proteinaceous extracellular matrix Molecular Function:protein binding; zinc ion binding; metalloendopeptidase activity Biological Process: cell migration; proteolysis involved in cellular protein catabolic process; cell-matrix adhesion; negative regulation of chondrocyte differentiation; regulation of inflammatory response; proteoglycan catabolic process |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P58397 |
| NCBI GenInfo Identifier: | 51558724 |
| NCBI Gene ID: | 81792 |
| NCBI Accession: | NP_112217.2 |
| UniProt Secondary Accession: | P58397,Q6UWL3, A2RRN9, A5D6V6, |
| UniProt Related Accession: | P58397 |
| Molecular Weight: | 168,460 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
| NCBI Official Symbol: | ADAMTS12 |
| NCBI Official Synonym Symbols: | PRO4389 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 12 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 12 |
| Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
| UniProt Gene Name: | ADAMTS12 |
| UniProt Entry Name: | ATS12_HUMAN |
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