ADAMTS1 Antibody (PACO20984)
- SKU:
- PACO20984
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ADAMTS1 Antibody (PACO20984) |
| Antibody SKU: | PACO20984 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human ADAMTS1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20984(ADAMTS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20984(ADAMTS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. |
| Synonyms: | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
| UniProt Protein Function: | ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. |
| UniProt Protein Details: | Protein type:Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted Chromosomal Location of Human Ortholog: 21q21.2 Cellular Component: basement membrane; cytoplasm; cytoplasmic vesicle Molecular Function:heparin binding; metalloendopeptidase activity; metallopeptidase activity; zinc ion binding Biological Process: integrin-mediated signaling pathway; kidney development; negative regulation of cell proliferation; ovulation from ovarian follicle; proteolysis |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHI8 |
| NCBI GenInfo Identifier: | 124053460 |
| NCBI Gene ID: | 9510 |
| NCBI Accession: | Q9UHI8.4 |
| UniProt Secondary Accession: | Q9UHI8,Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80, D3DSD5, |
| UniProt Related Accession: | Q9UHI8 |
| Molecular Weight: | 105,358 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 1 |
| NCBI Official Symbol: | ADAMTS1 |
| NCBI Official Synonym Symbols: | C3-C5; METH1 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
| UniProt Synonym Protein Names: | METH-1 |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS1 |
| UniProt Entry Name: | ATS1_HUMAN |
| Antibodies | ELISA Kits |
| Anti-ADAMTS1 Antibody (CAB15356) | Human ADAMTS1 ELISA Kit |
| ADAMTS1 Antibody (PACO06233) | Human A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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