Antibody Name:	ADAM29 Antibody (PACO19057)
Antibody SKU:	PACO19057
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human ADAM29

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19057(ADAM29 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO19057(ADAM29 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein.

Synonyms:

ADAM metallopeptidase domain 29

UniProt Protein Function:	ADAM29: a member of the ADAM (a disintegrin and metalloprotease domain) family of Cancer-Testis Antigen (CTAs). CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins. May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Has been found to be frequently mutated in melanoma. Mutations may play a role in melanoma progression and metastasis. Expressed in leukemias at the mRNA level. Three isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Protease; Cancer Testis Antigen (CTA); Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q34 Cellular Component: integral to plasma membrane Molecular Function:zinc ion binding; metallopeptidase activity; metalloendopeptidase activity Biological Process: spermatogenesis; proteolysis
NCBI Summary:	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UKF5
NCBI GenInfo Identifier:	73765552
NCBI Gene ID:	11086
NCBI Accession:	NP_055084
UniProt Related Accession:	Q9UKF5
Molecular Weight:
NCBI Full Name:	disintegrin and metalloproteinase domain-containing protein 29 preproprotein
NCBI Synonym Full Names:	ADAM metallopeptidase domain 29
NCBI Official Symbol:	ADAM29
NCBI Official Synonym Symbols:	CT73; svph1
NCBI Protein Information:	disintegrin and metalloproteinase domain-containing protein 29
UniProt Protein Name:	Disintegrin and metalloproteinase domain-containing protein 29
UniProt Synonym Protein Names:	Cancer/testis antigen 73; CT73
UniProt Gene Name:	ADAM29
UniProt Entry Name:	ADA29_HUMAN