Name: ACTN2/ACTN3 Antibody (PACO06231)
SKU: PACO06231
Availability: OutOfStock

Antibody Name:	ACTN2/ACTN3 Antibody (PACO06231)
Antibody SKU:	PACO06231
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF
Recommended Dilutions:	ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the N-terminal region of human Actinin- α 2/3.

Form:	Liquid
Storage Buffer:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western Blot analysis of HuvEc MCF7 PC12 cells using Actinin- alpha 2/3 Polyclonal Antibody.
	Western Blot analysis of HuvEc cells using Actinin-alpha 2/3 Polyclonal Antibody.

Synonyms:

ACTN2; α-actinin-2; α-actinin skeletal muscle isoform 2; F-actin cross-linking protein; ACTN3; α-actinin-3; α-actinin skeletal muscle isoform 3; F-actin cross-linking protein

UniProt Protein Function:	ACTN2: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the alpha-actinin family.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 1q42-q43 Cellular Component: cortical actin cytoskeleton; cytoskeleton; focal adhesion; extracellular region; dendritic spine; actin filament; pseudopodium; Z disc; cytosol; filopodium Molecular Function:actin filament binding; protein dimerization activity; integrin binding; identical protein binding; protein binding; LIM domain binding; structural constituent of muscle; cytoskeletal protein binding; titin binding; calcium ion binding; FATZ binding; thyroid hormone receptor coactivator activity Biological Process: focal adhesion formation; platelet activation; negative regulation of potassium ion transport; positive regulation of potassium ion transport; muscle filament sliding; protein homotetramerization; regulation of apoptosis; synaptic transmission; regulation of membrane potential; platelet degranulation; microspike biogenesis; blood coagulation; cell adhesion Disease: Cardiomyopathy, Dilated, 1aa
NCBI Summary:	Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
UniProt Code:	P35609
NCBI GenInfo Identifier:	543742
NCBI Gene ID:	88
NCBI Accession:	P35609.1
UniProt Secondary Accession:	P35609,Q86TF4, Q86TI8, B1ANE4, B2RCS5,
UniProt Related Accession:	P35609
Molecular Weight:	103,920 Da
NCBI Full Name:	Alpha-actinin-2
NCBI Synonym Full Names:	actinin, alpha 2
NCBI Official Symbol:	ACTN2
NCBI Official Synonym Symbols:	CMD1AA
NCBI Protein Information:	alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle
UniProt Protein Name:	Alpha-actinin-2
UniProt Synonym Protein Names:	Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein
Protein Family:	Alpha-actinin
UniProt Gene Name:	ACTN2
UniProt Entry Name:	ACTN2_HUMAN