Name: ACTN1/ACTN2/ACTN3/ACTN4 Antibody (PACO22008)
SKU: PACO22008
Availability: OutOfStock

Antibody Name:	ACTN1/ACTN2/ACTN3/ACTN4 Antibody (PACO22008)
Antibody SKU:	PACO22008
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from internal of human ACTN4.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from 293 cells, HeLa cells and A549 cells, using ACTN4 antibody.

Background:	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Synonyms:	AAC4; Alpha-actinin 4; F-actin cross linking protein; Non-muscle alpha-actinin 4; actinin

UniProt Protein Function:	ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene.
UniProt Protein Details:	Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 14q24\|14q22-q24 Cellular Component: extracellular space; cortical actin cytoskeleton; focal adhesion; extracellular region; dendritic spine; fascia adherens; pseudopodium; cytosol; Z disc; ruffle; cell projection; cytoplasm; plasma membrane; stress fiber; nucleus Molecular Function:actin filament binding; integrin binding; protein domain specific binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; double-stranded RNA binding; calcium ion binding; vinculin binding Biological Process: regulation of apoptosis; actin crosslink formation; focal adhesion formation; platelet activation; actin filament bundle formation; extracellular matrix organization and biogenesis; platelet degranulation; negative regulation of cell motility; blood coagulation Disease: Bleeding Disorder, Platelet-type, 15
NCBI Summary:	Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P12814
NCBI GenInfo Identifier:	46397817
NCBI Gene ID:	87
NCBI Accession:	P12814.2
UniProt Secondary Accession:	P12814,Q1HE25, Q9BTN1, B3V8S3, B4DHH3, B7TY16,
UniProt Related Accession:	P12814
Molecular Weight:	892
NCBI Full Name:	Alpha-actinin-1
NCBI Synonym Full Names:	actinin, alpha 1
NCBI Official Symbol:	ACTN1
NCBI Official Synonym Symbols:	BDPLT15
NCBI Protein Information:	alpha-actinin-1; actinin 1 smooth muscle; non-muscle alpha-actinin-1; F-actin cross-linking protein; alpha-actinin cytoskeletal isoform
UniProt Protein Name:	Alpha-actinin-1
UniProt Synonym Protein Names:	Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
Protein Family:	Alpha-actinin
UniProt Gene Name:	ACTN1
UniProt Entry Name:	ACTN1_HUMAN