| UniProt Protein Function: | ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.2.-Chromosomal Location of Human Ortholog: 1p32.3Cellular Component: cytoplasmMolecular Function: acyl-CoA hydrolase activity; lipid bindingBiological Process: response to temperature stimulus; response to cold; fatty acid metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q8WXI4 |
| NCBI GenInfo Identifier: | 21363000 |
| NCBI Gene ID: | 26027 |
| NCBI Accession: | Q8WXI4.1 |
| UniProt Secondary Accession: | Q8WXI4,O75187, Q52LP1, Q53ER9, Q96DI1, Q9H883, B1AQ22 D3DQ50 |
| UniProt Related Accession: | Q8WXI4 |
| Molecular Weight: | 67,152 Da |
| NCBI Full Name: | Acyl-coenzyme A thioesterase 11 |
| NCBI Synonym Full Names: | acyl-CoA thioesterase 11 |
| NCBI Official Symbol: | ACOT11 |
| NCBI Official Synonym Symbols: | BFIT; THEA; THEM1; STARD14 |
| NCBI Protein Information: | acyl-coenzyme A thioesterase 11; START domain containing 14; acyl-CoA thioester hydrolase 11; adipose-associated thioesterase; brown fat-inducible thioesterase; thioesterase, adipose associated; thioesterase superfamily member 1; StAR-related lipid transfer (START) domain containing 14 |
| UniProt Protein Name: | Acyl-coenzyme A thioesterase 11 |
| UniProt Synonym Protein Names: | Acyl-CoA thioester hydrolase 11; Adipose-associated thioesterase; Brown fat-inducible thioesterase; BFIT |
| Protein Family: | Acyl-coenzyme A thioesterase |
| UniProt Gene Name: | ACOT11 |
| UniProt Entry Name: | ACO11_HUMAN |
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